The only problem with Nyquist is that two samples per cycle of a waveform, say at 22,050 Hz., is insufficient for any waveform other than a square wave, either straight up at a relative output of 1 volt or straight down at a relative 0 (zero) volt. Any complex waveform might instead use a minimum of 16 samples to represent one waveform frequency cycle divided into segments of 22.5 degrees each.
When combined in the analog output, the total number of angles would equal 360 degrees, similar to one complete rotation of a Flipper in Visual Pinball. The maximum number of degrees in one frequency cycle is 360.
Nyquist might apply per degree of cycle; that the most accurate digital-to-analog conversion would require two samples per degree.
The rule of thumb is, with a fixed sampling rate, the higher the audio frequency, the fewest number of samples produced per cycle of audio frequency. The lowest bass frequencies then have the largest number of samples per cycle.
Due to the extra number of samples, many of these bass frequency samples are redundant and offer no change in the output waveform, which was part of the reason for developing the Squawk and Talk compression system, to cut down and compress the number of redundant samples as the cost of memory was exorbitant in '79-'80.